发明名称 |
SPHINGOLIPIDS POLYALKYLAMINE CONJUGATES FOR USE IN TRANSFECTION |
摘要 |
<p>The present invention concerns the use of a sphingoid-polyalkylamine conjugate as a capturing agent of biologically active molecules, such as antigens. In a particular embodiment, the spinogid-polyalkylamines are used for the preparation of pharmaceutical composition for modulating the immune response of a subject. Other aspects of the invention concern methods for modulating the immune response of a subject by the use of the conjugate, complexes comprising, the sphingoid-polyalkylamine conjugate in combination with a biologically active molecule capable of modulating an immune response of a subject, compositions comprising the conjugate as well as kits making use of said conjugate. A preferred conjugate according to the invention is N palmitoyl D-erythro sphingosyl 1 carbamoyl spermine.</p> |
申请公布号 |
EP1638611(A1) |
申请公布日期 |
2006.03.29 |
申请号 |
EP20040744874 |
申请日期 |
2004.06.17 |
申请人 |
YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREWUNIVERSITY OF JERUSALEM;BIOLAB LTD. |
发明人 |
BARENHOLZ, YECHEZKEL;SIMBERG, DMITRI |
分类号 |
A61K31/132;A61K38/47;A61K39/08;A61K39/145;A61K39/29;A61K39/39;A61K48/00;A61P37/02;A61P43/00;C07C271/20;(IPC1-7):A61K48/00 |
主分类号 |
A61K31/132 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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