发明名称 |
Synthesis of irbesartan |
摘要 |
Provided are a method of making irbesartan via a Suzuki coupling reaction and a novel intermediate, 2-butyl-3-(4'-bromobenzyl)-1,3-diazaspiro[4.4]non-1-ene-4-one, for such process. The novel process includes the step of reacting such intermediate with a protected imidazolephenylboronic acid.
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申请公布号 |
US7019148(B2) |
申请公布日期 |
2006.03.28 |
申请号 |
US20040759906 |
申请日期 |
2004.01.16 |
申请人 |
TEVA PHARMACEUTICAL INDUSTRIES, LTD. |
发明人 |
NISNEVICH GENNADY;RUKHMAN IGOR;PERTSIKOV BORIS;KAFTANOV JULIA;DOLITZKY BEN-ZION |
分类号 |
C07D257/04;A61K31/41;C07D235/02;C07D237/02;C07D403/10 |
主分类号 |
C07D257/04 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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