发明名称 |
Method for ex vivo immunization using heterologous intact bispecific and/or trispecific antibodies |
摘要 |
According to the invention there is described a method for ex vivo immunization of humans and animals comprising the following steps: a) isolating autologous tumor cells; b) treating the tumor cells to prevent the survival thereof following reinfusion; c) incubating the thus treated tumor cells with intact heterologous bispecific and/or trispecific antibodies showing the following properties: alpha-binding to a T cell; beta-binding to at least one antigen on a tumor cell; gamma-binding, by their Fc portion (in the case of bispecific antibodies), or by a third specificity (in the case of trispecific antibodies) to Fc receptor-positive cells. |
申请公布号 |
US7018632(B2) |
申请公布日期 |
2006.03.28 |
申请号 |
US19980094921 |
申请日期 |
1998.06.15 |
申请人 |
GSF-FORSCHUNGSZENTRUM FUER UMWELT UND GESUNDHEIT GMBH |
发明人 |
LINDHOFER HORST;KOLB HANS-JOACHIM;ZEIDLER REINHARD;BORNKAMM GEORG |
分类号 |
A61K39/395;C12N15/09;A61K35/12;A61K35/14;A61K39/00;A61P35/00;C07K16/28;C07K16/30;C12P21/08 |
主分类号 |
A61K39/395 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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