Composition and method for inhibiting platelet aggregation

摘要

The present invention provides novel compounds of dinucleotide polyphosphates and the method of preventing or treating diseases or conditions associated with platelet aggregation. The method comprises administering systemically to a patient a pharmaceutical comprising a purinergic P2_tau receptor antagonist, in an amount effective to elevate its extracellular concentration to bind to P2_tau receptors and inhibit P2_tau receptor-mediated platelet aggregation. Methods of systemic administration include injection by intravenous, intramuscular, intrasternal and intravitreal routes, infusion, transdermal administration, oral administration, rectal administration and intra-operative instillation.