Compositions and methods for reducing serum glucose and triglyceride levels in diabetic mammals

摘要

Diabetic mammals are treated with compounds that are significantly more efficacious as agonists of RXR_beta retinoid receptors than as agonists of RXR_alpha or RXR_gamma retinoid receptors. The treatment reduces serum glucose and triglyceride levels of the mammals without the undesirable side effects of reducing serum thyroxine levels and a transient increase in serum triglyceride levels Compounds suitable for use in the methods of treatments of the present invention are selected by testing and identifying compounds of selective or specific efficacy as agonists of RXR_beta retinoid receptors in preference over RXR_alpha and/or RXR_gamma retinoid receptors. Novel compounds used in the methods of the invention have Formula 1 where the variables are defined as disclosed in the specification.