RECOMBINANT ANTIBODIES AND FRAGMENTS RECOGNISING GANGLIOSIDE N-GLYCOLYL-GM3 AND USE THEREOF IN THE DIAGNOSIS AND TREATMENT OR TUMOURS
摘要
<p>The present invention is mainly related with the monoclonal antibody that recognizes antigens that contained the N-glycolil GM3 ganglioside and not other gangliosides of the N-glycolil or N-acetyl type, or the sulphated glycolipids. More specifically the present invention is related with the peptides sequences that codify a recombinant monoclonal antibody derived from the 14F7 antibody that recognizes the N-glycolil GM3 ganglioside, or fragments derived from it and pharmaceutical compositions containing said recombinant antibody or its fragments and its use in diagnosis or therapy of berast cancer and melanoma.</p>
申请公布号
LT2005101(A)
申请公布日期
2006.03.27
申请号
LT20050000101
申请日期
2005.11.21
申请人
CENTRO DE IMMUNOLOGIA MOLECULAR
发明人
ROQUE NAVARRO, LOUDES, TATIANA;MATEO DE ACOSTA DEL RIO, CRISTINA, MARIA;RODRIGUEZ GONZALEZ, MABEL;ROJAS DORANTES, GERTRUDIS;TALAVERA PEREZ, ARIEL;MORENO FRAIS, ERNESTO