| 摘要 |
This invention provides neuromedin U 2 receptor (NMU-2R) agonists. This invention further provides a method for screening and identification of said agonist. This invention also provides the core structure for NMU-2R agonists. This invention provides that the agonist can effectively reduced body weight of high fat diet induced obese rats and normal C57BL/6 mice. In addition, the compound increased the insulin sensitivity and decreased blood glucose level of obese rats. Specifically, this invention provides that Rutin and the related compounds could be developed into effective therapeutic drugs for obesity and non-insulin dependent diabetes mellitus (NIDDM).
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