发明名称 |
Nuclear factors associated with transcriptional regulation |
摘要 |
Constitutive and tissue-specific protein factors which bind to transcriptional regulatory elements of Ig genes (promoter and enhancer) are described. The factors were identified and isolated by an improved assay for protein-DNA binding. Genes encoding factors which positively regulate transcription can be isolated and employed to enhance transcription of Ig genes. In particular, NF-kB, the gene encoding NF-kB, IkB and the gene encoding IkB and uses therefor.
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申请公布号 |
US2006063709(A1) |
申请公布日期 |
2006.03.23 |
申请号 |
US20020037415 |
申请日期 |
2002.01.04 |
申请人 |
BALTIMORE DAVID;SEN RANJAN;SHARP PHILLIP A;SINGH HARINDER;STAUDT LOUIS;LEBOWITZ JONATHAN;BALDWIN ALBERT S JR;CLERC ROGER G;CORCORAN LYNN M;BAEUERLE PATRICK A;LENARDO MICHAEL J;FAN CHEN-MING;MANIATIS THOMAS P |
发明人 |
BALTIMORE DAVID;SEN RANJAN;SHARP PHILLIP A.;SINGH HARINDER;STAUDT LOUIS;LEBOWITZ JONATHAN;BALDWIN ALBERT S.JR.;CLERC ROGER G.;CORCORAN LYNN M.;BAEUERLE PATRICK A.;LENARDO MICHAEL J.;FAN CHEN-MING;MANIATIS THOMAS P. |
分类号 |
A61K38/17;C07H21/04;C07K14/16;C07K14/47;C12N15/85;C12Q1/68;G01N33/68 |
主分类号 |
A61K38/17 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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