The invention provides novel compositions of water-insoluble corticosteroid drug in optional combination with antimicrobial agents and surfactants and either ionic polymers or very low concentrations of non-ionic polymer for topical, otic, and ophthalmic treatment. The invention provides stable aqueous suspensions where the ingredients remain in such a state so as to allow for immediate re-suspension, when desired, even after extended periods of settling. The invention provides also a method for treating inflammation with low systemic absorption and side effects of the corticosteroid.
