NOVEL PYRIDINONE DERIVATIVES AND THEIR USE AS POSITIVE ALLOSTERIC MODULATORS OF MGLUR2-RECEPTORS

摘要

The present invention relates to novel compounds, in particular novel
pyridinone derivat ives according to Formula (I) X R1 N Y (I) R2 R3 wherein
all radicals are defined in the application. The compounds according to the
invention are positive allosteric modulators of metabotropic receptors - subt
ype 2 ("mGluR2") which are useful for the treatment or prevention of
neurological and psychiatric disorders associated with glutamate dysfunction
and diseases in which the mGluR2 subtype of metabotropic receptors is
involved. In particular, such diseases are central nervous system disorders
selected from the group of anxiety, schizophrenia, migraine, depression, and
epilepsy. The invention is also directed to pharmaceutical compositions and
processes to prepare such compounds and compositions, as well as to the use of
such compounds for the prevention and treatment of such diseases in which
mGluR2 is involved.