发明名称 |
METHODS AND DOSAGE FORMS WITH MODIFIED VISCOSITY LAYERS |
摘要 |
Dosage forms and methods for providing a modulated release of cyclobenzaprine are provided. The sustained release dosage forms provide therapeutically effective average steady-state plasma cyclobenzaprine concentrations when administered once per day. The composition of the delay layer and the composition of the drug layer are characterized by the viscosity of the hydrated delay layer remaining higher than the viscosity of the hydrated drug layer during operation in one embodiment. The result is greater uniformity in the release rate from the core providing a more optimal ascending release rate. In other embodiments, the hydrated delay layer has a viscosity that is lower than the viscosity of the hydrated drug layer as well as a hydrated delay layer that is substantially similar to the hydrated drug layer. |
申请公布号 |
WO2004064772(A3) |
申请公布日期 |
2006.03.23 |
申请号 |
WO2004US00531 |
申请日期 |
2004.01.09 |
申请人 |
ALZA CORPORATION |
发明人 |
SUBRAMANIAN, RAMKUMAR;BARCLAY, BRIAN, L.;HATAMKHANY, ZAHEDEH;ZHANG, YUXIANG;GUMUCIO, FERNANDO |
分类号 |
A61K;A61K9/00;A61K9/24;A61K9/28;A61K9/52;A61K31/135;A61K31/55 |
主分类号 |
A61K |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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