HIGHLY-AQUEOUS NON-RESPIRABLE AEROSOLS CONTAINING BIOLOGICALLY-ACTIVE INGREDIENTS METHOD OF MAKING AND DEVICE THEREFOR

摘要

A non-respirable aerosol, particularly a non-respirable aerosol comprising a biologically-effective amount of a biologically-active agent dissolved, emulsified, or suspended in a highly-aqueous liquid carrier vehicle. The highly-aqueous liquid carrier vehicle comprises about 60 wt% to about 100 wt% water, about 0 wt% to about 40 wt% of a co-solvent, about 0.05 wt% to about 10 wt% of an acceptable surfactant, and about 0 wt% to about 10 wt% of an excipient. The non-respirable aerosol is substantially monodisperse when dispensed from a sprayhead assembly comprising a preferably linear array of a plurality of nozzles and at least one counter electrode adapted to substantially equalize the charge fields of the plurality of nozzles.