PHOSPHORYLATED VIMENTIN SERVING AS A MARKER OF THE AGGRESSIVENESS AND/OR INVASIVENESS OF TUMORS
摘要
<p>The invention relates to a novel method used for determining the aggressiveness and/or invasiveness of a tumor. The invention also relates to a method for identifying an anticancer agent that makes it possible to reduce the aggressiveness and/or invasiveness of a tumor. The invention is based on the inventors' findings that vimentin produced by the cancer cells can be a marker of the aggressiveness and/or invasiveness of a tumor. This maker capacity is not associated with expression of the vimentin in the cancer cells but is with a post-translational transformation of this different protein according to the degree of aggressiveness and/or invasiveness.</p>
申请公布号
WO2006030023(A1)
申请公布日期
2006.03.23
申请号
WO2005EP54598
申请日期
2005.09.15
申请人
GENOME EXPRESS SA;INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM);BOUAMRANI, ALI;GAY, EMMANUEL;ISSARTEL, JEAN-PAUL;BERGER, FRANCOIS