| 发明名称 |
MODULATION OF XBP-1 ACTIVITY FOR TREATMENT OF METABOLIC DISORDERS |
| 摘要 |
<p>The invention provides methods and compositions for modulating the expression, processing, post-translational modification, stability and/or activity of XBP-1 protein, or a protein in a signal transduction pathway involving XBP-1 to treat metabolic disorders, e.g., type II diabetes. The present invention also pertains to methods for identifying compounds that modulate the expression, processing, post-translational modification, and/or activity of XBP-1 protein or a molecule in a signal transduction pathway involving XBP-1.</p> |
| 申请公布号 |
WO2006031930(A2) |
申请公布日期 |
2006.03.23 |
| 申请号 |
WO2005US32840 |
申请日期 |
2005.09.15 |
| 申请人 |
THE PRESIDENT AND FELLOWS OF HARVARD COLLEGE;HOTAMISLIGIL, GOKHAN, S.;GLIMCHER, LAURIE, H.;OZCAN, UMUT |
发明人 |
HOTAMISLIGIL, GOKHAN, S.;GLIMCHER, LAURIE, H.;OZCAN, UMUT |
| 分类号 |
A61K31/401;A61K31/13;A61K31/192;A61K31/225;A61K31/366 |
主分类号 |
A61K31/401 |
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