NEW S-OLIGONUCLEOTIDE CONJUGATE AND ANTI-SENSE AGENT CONTAINING THE SAME AS ACTIVE INGREDIENT

摘要

PROBLEM TO BE SOLVED: To provide a new conjugate which especially exhibits a high activity-inhibiting action against a telomerase in human leukemic cell extracts and gives a double strand hybrid between complementary DNAs in a stable state.

SOLUTION: This phosphorothioate oligonucleotide conjugate is represented by the general formula [A1is an alkylene or an alkylene interrupted by an oxygen atom; A2is an alkylene; R is the residue of a peptide, sugar or functional amine; (n) is 0 or 1].

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