Phenotypes and the cells that exhibit those phenotypes are described. The phenotype may be established as a "snapshot" of the cells at a particular time or it may be established as a variation in features over time, or as some combination of these "static" and "dynamic" characterizations. The phenotype may be characterized by at least the following features: (a) chromosomes that approach metaphase but fail to separate and maintain alignment compared to a control cell or cell population; (b) a bipolar spindle that is at least about 10% longer than a corresponding metaphase mitotic spindle from the control cell or cell population; and (c) during interphase the cell or population of cells exhibits a phenotype that is substantially similar to that of the interphase cells of the control cell or cell population.
申请公布号
WO2006031273(A2)
申请公布日期
2006.03.23
申请号
WO2005US21527
申请日期
2005.06.16
申请人
CYTOKINETICS, INC.;ADAMS, CYNTHIA, LYNN;DE LA ROSA, REGINALD, NORMAN;RAMCHANDANI, SHYAMLAL
发明人
ADAMS, CYNTHIA, LYNN;DE LA ROSA, REGINALD, NORMAN;RAMCHANDANI, SHYAMLAL