NOVEL FORMS OF FLUVASTATIN SODIUM, PROCESSES FOR PREPARATION AND PHARMACEUTICAL COMPOSITIONS THEREOF

摘要

Provided are substantially amorphous fluvastatin sodium and amorphous Form R6 and R-14 of fluvastatin sodium. Also provided are crystalline forms of fluvastatin sodium designated as Forms R-1, R-2, R-3, R-4, R-5, R-7, R-8, R-9, R-10, R-11, R-12, R-13, R-15 and R-16 and an anhydrous crystalline form. Also provided are processes for preparing such polymorphic forms and pharmaceutical compositions thereof. Also provided are methods for antagonizing HMG-CoA comprising administering to a mammal therapeutically effective amounts of the compounds described herein.