ICA512 COUPLES INSULIN SECRETION AND GENE EXPRESSION IN ß-CELLS

摘要

The present invention relates to a method for stimulating expression of peptide hormones in peptide-hormone secreting endocrine cells or neurons comprising the step of promoting in said cells the presence or activity of ICA512, a derivative or a fragment thereof that may be cleaved by mu-calpain giving rise to a C-terminal fragment of ICA512 having the capability to be targeted to the nucleus. It is preferred that said endocrine cells are beta­cells and that said peptide hormone is insulin.