METHOD FOR PRODUCING ABNORMAL AMINO ACID USING BACTERIUM OF ENTEROBACTERIACEAE FAMILY WHICH HAS ALL ACETOHYDROXY ACID SYNTHASE INACTIVATED

摘要

PROBLEM TO BE SOLVED: To provide an efficient fermentation method of a non-proteinogenic amino acid (abnormal amino acid; L-norleucine, L-norvaline, etc.) for production of a bioactive peptide analogue. SOLUTION: The method for producing the abnormal amino acid such as the norleucine and the norvaline involves using a bacterium of the Enterobacteriaceae family, especially a bacterium of the genus Escherichia in which the whole acetohydroxy acid synthases (AHAS) are inactivated. COPYRIGHT: (C)2006,JPO&NCIPI