发明名称 |
REDUCING ER STRESS IN THE TREATMENT OF OBESITY AND DIABETES |
摘要 |
Endoplasmic reticulum stress has been found to be associated with obesity. Therefore, agents that reduce or prevent ER stress may be used to treat diseases associated with obesity including peripheral insulin resistance, hypergylcemia, and type 2 diabetes. Two compounds which have been shown to reduce ER stress and to reduce blood glucose levels include 4-phenyl butyric acid (PBA), tauroursodeoxycholic acid (TUDCA), and trimethylamine <i |
申请公布号 |
WO2006031931(A2) |
申请公布日期 |
2006.03.23 |
申请号 |
WO2005US32841 |
申请日期 |
2005.09.15 |
申请人 |
THE PRESIDENT AND FELLOWS OF HARVARD COLLEGE;HOTAMISLIGIL, GOKHAN, S.;OZCAN, UMUT |
发明人 |
HOTAMISLIGIL, GOKHAN, S.;OZCAN, UMUT |
分类号 |
A61K31/401;A61K31/13;A61K31/192;A61K31/225;A61K31/366 |
主分类号 |
A61K31/401 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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