| 摘要 |
A method of enhancing the production of gametes in a transgenic non-human animal is carried out by: (a) providing a transgenic non-human animal comprising cells that contain: (i) a response element; (ii) a nucleic acid encoding FSHbeta operatively associated with said response element; (iii) an FSHbeta promoter; (iv) an FSHbeta locus control region operatively associated with said FSHbeta promoter; and (v) a nucleic acid encoding a ligand-controllable receptor operatively associated with said FSHbeta promoter, wherein said receptor binds to said response element in the presence of said ligand when expressed in a host cell; and (b) administering said ligand to said animal in an amount effective to (i) stimulate the production of FSHbeta in said animal above that found in a corresponding untransformed type animal; and (ii) stimulate the production of gametes in said animal to a level greater than that found in the corresponding untransformed animal.
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