发明名称 |
Interleukin-15 antagonist peptide |
摘要 |
<p>Current invention is related to the molecular pharmacology branch particularly to a peptide belonging to the Interleukin-15 sequence (IL-15) which is able to inhibit IL-15 biological activity, analogues or mimetic of such peptides. In the current invention it is shown that the peptide inhibits both IL-15-induced T cells proliferation upon binding to the IL15 receptor a subunit (IL15Rα) and TNFα-mediated apoptosis. Besides, this invention is related to the use of this peptide in the treatment of several pathologies where aberrant IL-15 or IL-15Rαexpression is associated to the disease progression.</p> |
申请公布号 |
AU2005284529(A1) |
申请公布日期 |
2006.03.23 |
申请号 |
AU20050284529 |
申请日期 |
2005.09.16 |
申请人 |
CENTRO DE INGENIERIA GENETICA Y BIOTECNOLOGIA |
发明人 |
HAYDEE GERONIMO PEREZ;SILVIO ERNESTO PEREA RODRIGUEZ;ANIA CABRALES RICO;ALICIA SANTOS SAVIO;CELIA AURORA ARRIETA AGUERO;OSVALDO REYES ACOSTA |
分类号 |
C07K14/54;A61K38/20;A61K39/00;C07K16/24;C12N15/24 |
主分类号 |
C07K14/54 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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