发明名称 |
INHIBITION OF APOPTOSIS-SPECIFIC ELF-5A ( EIF-5A1) WITH ANTISENSE OLIGONUCLEOTIDES AND siRNAs AS ANTI-INFLAMMATORY THERAPEUTICS |
摘要 |
<p>The present invention relates to apoptosis specific eucaryotic initiation factor 5A (eIF-5A), referred to as apoptosis-specific eIF-5A or eIF5A1, nucleic acids and polypeptides and methods for inhibiting or suppressing apoptosis in cells using antisense nucleotides or siRNAs to inhibit expression of apoptosis-specific eIF-5A. The invention also relates to suppressing or inhibiting expression of pro-inflammatory cytokines or inhibiting expression of pro-inflammatory cytokines or inhibiting activation of NFkB by inhibiting expression of apoptosis-specific eIF-5A.</p> |
申请公布号 |
EP1636364(A2) |
申请公布日期 |
2006.03.22 |
申请号 |
EP20040785931 |
申请日期 |
2004.06.07 |
申请人 |
SENESCO TECHNOLOGIES, INC. |
发明人 |
THOMPSON, JOHN, E.;TAYLOR, CATHERINE |
分类号 |
A61K38/00;C12N15/113;(IPC1-7):C12N15/11;A61P37/00;A61P27/00;A61K31/713 |
主分类号 |
A61K38/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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