Process for the inactivation of enveloped viruses

摘要

Inactivating lipid-encapsulated viruses comprises incubating an intact virus with a polysorbate detergent for a time sufficient to inactivate the virus without destroying its structural integrity : Independent claims are also included for: (1) vaccine comprising a viral preparation as above; (2) stable vaccine composition comprising comprising inactivated viruses and a stabilizer, where the whole viruses are intact and exhibit structural integrity; (3) viral preparation comprising inactivated viruses in which the whole viruses are intact and exhibit structural integrity. ACTIVITY : Virucide; Anti-HIV. MECHANISM OF ACTION : Vaccine.