发明名称 |
Pyrrhocoricin-derived peptides, and methods of use thereof |
摘要 |
Modifications of the peptide pyrrhocoricin permit the production of a variety of anti-bacterial or anti-fungal peptides having general formula R<SUP>1</SUP>-Asp-Lys-Gly-X-Y-Leu-Pro-Arg-Pro-Thr-Pro-Pro-Arg-Pro-Ile-Tyr-X'-Y'-R<SUP>2 </SUP>SEQ ID NO: 1 or multimeric compositions containing more than a single peptide of that formula. These peptides may be straight chain or cyclic peptides, and may contain one or more non-cleavable bonds. These peptides are characterized by anti-bacterial or anti-fungal activity and metabolic stability in mammalian serum. These peptides are useful in anti-bacterial or anti-fungal pharmaceutical compositions and for further drug development or identification of other antibiotic or anti-fungal compounds.
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申请公布号 |
US7015309(B1) |
申请公布日期 |
2006.03.21 |
申请号 |
US20010980804 |
申请日期 |
2001.12.03 |
申请人 |
THE WISTAR INSTITUTE OF ANATOMY AND BIOLOGY |
发明人 |
OTVOS LASZLO |
分类号 |
C07K1/00 |
主分类号 |
C07K1/00 |
代理机构 |
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代理人 |
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