HYDROXYAZEPANES AS INHIBITORS OF GLYCOSIDASE AND HIV PROTEASE

摘要

Hydroxyazepanes display inhibitory activity with respect to glycosidase, with K i values from moderate to low micromolar range. Benzyl and 3,6-dibenzyl derivatives of hydroxyazepanes display inhibitory activity with respect to HIV protease. These compounds are synthesized either by chemoenzymatic or chemical methodologies. Methods are provided for producing a tetrahydroxyazepane with the formula: (see formula I)