发明名称 |
ADENOVIRAL VECTORS FOR MUTANTS OF HUMAN INTERLEUKIN 6 (HIL-6) WITH HIL-6 ANTAGONIST ACTIVITY, PHARMACEUTICAL COMPOSITIONS THEREWITH AND THEIR USES |
摘要 |
The subject matter of the present invention are recombinant defective adenoviruses comprising a heterologous DNA sequence coding for a mutein having the activity of human Interleukin 6 (hIL-6) antagonists or superantagonist. Moreover, the invention refers to therapeutical uses thereof, in particular for preparing pharmaceutical compositions for treating and/or preventing pathologies caused by hIL-6 overproduction. The subject matter of the present invention are recombinant defective adenoviruses comprising a heterologous DNA sequence coding for a mutein having the activity of human Interleukin 6 (hIL - 6) antagonists or superantagonist. Moreover, the invention refers to therapeutical uses thereof, in particular for preparing pharmaceutical compositions for treating and/or preventing pathologies cause d by hIL-6 overproduction.
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申请公布号 |
CA2266743(C) |
申请公布日期 |
2006.03.21 |
申请号 |
CA19972266743 |
申请日期 |
1997.09.24 |
申请人 |
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE;ISTITUTO DI RICERCHE DI BIOLOGIA MOLECOLARE P. ANGELETTI S.P.A. |
发明人 |
PERRICAUDET, MICHEL;CILIBERTO, GENNARO;SAVINO, ROCCO;SAGGIO, ISABELLA |
分类号 |
C12N15/09;C12N15/24;A61K38/00;A61K38/20;A61P35/00;C07K14/54;C12N15/861 |
主分类号 |
C12N15/09 |
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地址 |
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