发明名称 |
Mutation of dna polymerases from archaeobacteria |
摘要 |
The present invention relates to a variant archaeal DNA polymerase having a modified amino acid sequence of a wild-type amino acid sequence, the modified sequence being in the amino-terminal amino acids that comprise a uracil-binding pocket in the wild-type polymerase whereby the variant polymerase has reduced affinity for uracil than the wild-type polymerase. Such variant polymerases may be usefully employed in biological assay systems such as the polymerase chain reaction.
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申请公布号 |
US2006057682(A1) |
申请公布日期 |
2006.03.16 |
申请号 |
US20030511130 |
申请日期 |
2003.04.15 |
申请人 |
THE UNIVERSITY OF NEWCASTLE |
发明人 |
CONNOLLY BERNARD;FOGG MARK;PEARL LAURENCE |
分类号 |
C07H21/04;C12N15/09;C12N9/12;C12N9/22;C12N15/74;C12P19/34;C12Q1/68 |
主分类号 |
C07H21/04 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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