| 摘要 |
<p>A transdermal antiemesis system, preferably in the form of a drug-in-adhesive matrix patch, is disclosed, the system comprises an effective antiemesis amount of a selective serotonin (5-HT<SUB>3</SUB>) receptor antagonist as an antiemetic incorporated in a skin adhesive composition containing at least one permeation enhancer in an amount effective to provide a substantially uniform release of drug from the composition and a water-insoluble pressure-sensitive adhesive. A preferred antiemetic is granisetron base. The transdermal antiemesis system of this invention provides controlled release of the active antiemetic ingredient from the skin-contacting adhesive formulation of a transdermal patch, and maintains a substantially uniform, sustained transdermal delivery of the antiemetic.</p> |
| 申请人 |
NEXMED HOLDINGS, INC.;LEBO, DAVID, B.;LEE, JUNY;RYOO, JE PHIL;TOIGO, OLIVER, J., III;CUPO, FRANCIS |
发明人 |
LEBO, DAVID, B.;LEE, JUNY;RYOO, JE PHIL;TOIGO, OLIVER, J., III;CUPO, FRANCIS |
