NON HUMAN TRANSGENIC ANIMAL AS A MODEL OF NEURODEGENERATIVE DISEASES AND FOR THE EARLY DIAGNOSIS THEREOF

摘要

A non human transgenic animal able to express ubiquitarily an anti-NGF neutralizing antibody wherein said antibody is composed by an endogenous VH chain and by an exogenous VK chain; uses as an animal model to identify compounds with therapeutic activity, in particular for neurodegenerative pathologies. Method for the early prognosis and/or diagnosis of neurodegenerative diseases comprising the drawing of a peripheral biological fluid from a patient and the detection in said fluid of antibodies anti-NGF, or anti-TrkA or antibodies against proteins linked to NGF activity.