An embolic composition comprises microspheres formed of water-insoluble water-swellable anionic polymer having swollen diameter more than 100µm, and a cationic camptothecin compound, preferably irinotecan. The microspheres are preferably formed of crosslinked polyvinylalcohol, preferably of ethylenically unsaturated polyvinylalcohol macromer, crosslinked with anionic ethylenically unsaturated anionic comonomer. The compositions are used to treat hypervascular tumours for instance colorectal metastases of the liver.
申请公布号
WO2006027567(A2)
申请公布日期
2006.03.16
申请号
WO2005GB03431
申请日期
2005.09.06
申请人
BIOCOMPATIBLES UK LIMITED;LEWIS, ANDREW, LENNARD;STRATFORD, PETER, WILLIAM;GONZALEZ-FAJARDO, MARIA VICTORIA;TANG, YIQING
发明人
LEWIS, ANDREW, LENNARD;STRATFORD, PETER, WILLIAM;GONZALEZ-FAJARDO, MARIA VICTORIA;TANG, YIQING