DIAGNOSIS, PROGNOSIS AND IDENTIFICATION OF POTENTIAL THERAPEUTIC TARGETS OF MULTIPLE MYELOMA BASED ON GENE EXPRESSION PROFILING

摘要

Gene expression profiling is a powerful tool that has varied utility. It enables classification of multiple myeloma into subtypes and identifies genes directly involved in disease pathogensis and clinical manifestation. The present invention reported a 15-gene model that classifies myeloma into 7 groups. The present invention also used gene expression profiling in large uniformly treated population of patients with myeloma to identify genes associated with poor prognosis. It also demonstrated that over-expression of CKS 1 B gene, mainly due to gene amplification could impart poor prognosis in multiple myeloma. It is further contemplated that therapeutic strategies that directly target CKS 1 B or related pathways may represent novel and more specific means of treating high-risk myeloma and prevent its secondary evolution.