摘要 |
The invention relates to a pharmaceutical composition for rectal or vaginal application comprising as active substance a platinum complex of general formula I, wherein A each independently is an -NH3 group or an amino group containing 1 to 18 carbon atoms, B each independently is a halogen atom, a hydroxy group or a COOR group wherein R each independently is hydrogen atom or an alkyl, alkenyl, aryl, aralkyl, alkylamino or alkoxy group containing 1 to 10 carbon atoms or a functional derivatives of these groups, and X each independently is a halogen atom or a monocarboxylate group containing 1 to 20 carbon atoms, or X together form a dicarboxylate group containing 2 to 20 carbon atoms, and a hydrophilic gel-forming base, comprising gelatin, water and glycerol. The invention also relates to a method of manufacturing this composition, which is characterized in that the active substance is admixed with a thermally liquefied hydrophilic gel-forming base comprising gelatin, water and glycerol, and the obtained mixture is shaped. The invention also relates to use of this composition as a medicament for treatment of tumor diseases. |