发明名称 PHARMACEUTICAL COMPOSITION FOR RECTAL OR VAGINAL APPLICATION, METHOD OF MANUFACTURING AND USE AS MEDICAMENT THEREOF
摘要 The invention relates to a pharmaceutical composition for rectal or vaginal application comprising as active substance a platinum complex of general formula I, wherein A each independently is an -NH3 group or an amino group containing 1 to 18 carbon atoms, B each independently is a halogen atom, a hydroxy group or a COOR group wherein R each independently is hydrogen atom or an alkyl, alkenyl, aryl, aralkyl, alkylamino or alkoxy group containing 1 to 10 carbon atoms or a functional derivatives of these groups, and X each independently is a halogen atom or a monocarboxylate group containing 1 to 20 carbon atoms, or X together form a dicarboxylate group containing 2 to 20 carbon atoms, and a hydrophilic gel-forming base, comprising gelatin, water and glycerol. The invention also relates to a method of manufacturing this composition, which is characterized in that the active substance is admixed with a thermally liquefied hydrophilic gel-forming base comprising gelatin, water and glycerol, and the obtained mixture is shaped. The invention also relates to use of this composition as a medicament for treatment of tumor diseases.
申请公布号 WO2006026935(A2) 申请公布日期 2006.03.16
申请号 WO2005CZ00068 申请日期 2005.09.07
申请人 PLIVA-LACHEMA A.S.;FRANC, ALES;SOVA, PETR 发明人 FRANC, ALES;SOVA, PETR
分类号 A61K9/02;A61K31/282 主分类号 A61K9/02
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