MULTILAYER DOSAGE FORM COMPRISING A MATRIX THAT INFLUENCES RELEASE OF A MODULATORY SUBSTANCE

摘要

The invention relates to a multilayer dosage form for the controlled release of active substances, which substantially comprises a) optionally a neutral core (nonpareilles), b) an inner control layer, comprising a modulatory effective substance that is embedded in a matrix that influences release of a modulatory substance, said matrix comprising pharmaceutically acceptable polymers, waxes, resins and/or proteins and optionally an active substance, c) an active substance layer, comprising a pharmaceutically active substance and optionally a modulatory effective substance, d) an outer control layer, comprising at least 60 % by weight of one or more mixtures from a plurality of (meth)acrylate copolymers, 98 to 85 C₁ to C₄ alkyl esters of the (meth)acrylic acid and 2 to 15 % by weight of methacrylate monomers with a quaternary ammonium group in the alkyl group, and optionally up to 40 % by weight of additional pharmaceutically acceptable polymers. The dosage form is further characterized in that the layers additionally contain, in a manner known per se, pharmaceutically common adjuvants.