摘要 |
<p>The invention provides a composition comprising a mixture of polypeptides, wherein each polypeptide (a) is a copolymer of the amino acids L-glutamic acid, L-alanine, L-tyrosine, and L-lysine, and (b) may be in the form of a pharmaceutically acceptable salt; and wherein in the mixture (i) the polypeptides have an average molecular weight in the range 13,500 to 18,500 daltons, (ii) 13% to 38% of the polypeptides have a diethylamide group instead of a carboxyl group present at one end thereof, and (iii) 68% of the polypeptides have a molecular weight between 7,000 and 41,000 daltons. In an embodiment, the average molecular weight is 16,000 daltons, and processes for preparing and its uses.</p> |
申请人 |
TEVA PHARMACEUTICAL INDUSTRIES, LTD.;TEVA PHARMACEUTICALS USA, INC.;YEDA RESEARCH AND DEVELOPMENT CO. LTD. |
发明人 |
PINCHASI, IRIT;DOLITZKY, BEN-ZION;FRENKEL, ANTON;SCHWARTZ, MICHAL;ARNON, RUTH;AHARONI, RINA |