发明名称 |
SIX-MEMBERED HETEROCYCLES USEFUL AS SERINE PROTEASE INHIBITORS |
摘要 |
The present invention provides compounds of Formula (I) or a stereoisomer or pharmaceutically acceptable salt or solvate form thereof, wherein the variables A, L, Z, X1, X2, X3, X4, and X5 are as defined herein. The compounds of Formula (I) are useful as selective inhibitors of serine protease enzymes of the coagulation cascade and/or contact activation system; for example thrombin, factor Xa, factor XIa, factor IXa, factor VIIa and/or plasma kallikrein. In particular, it relates to compounds that are selective factor XIa inhibitors. This invention also relates to pharmaceutical compositions comprising these compounds and methods of treating thromboembolic and/or inflammatory disorders using the same.
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申请公布号 |
WO2005123680(B1) |
申请公布日期 |
2006.03.16 |
申请号 |
WO2005US20971 |
申请日期 |
2005.06.14 |
申请人 |
BRISTOL-MYERS SQUIBB COMPANY;CORTE, JAMES;HANGELAND, JON;QUAN, MIMI;SMALLHEER, JOANNE, M.;FANG, TIANAN |
发明人 |
CORTE, JAMES;HANGELAND, JON;QUAN, MIMI;SMALLHEER, JOANNE, M.;FANG, TIANAN |
分类号 |
A61K31/44;C07D213/02;C07D213/40;C07D213/55;C07D213/56;C07D213/57;C07D213/61;C07D213/64;C07D213/73;C07D213/74;C07D213/89;C07D239/26;C07D401/04;C07D401/10;C07D401/12;C07D401/14;C07D409/04;C07D409/14;C07D413/04;C07D413/14;(IPC1-7):C07D213/02 |
主分类号 |
A61K31/44 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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