发明名称 |
METHODS FOR SCREENING FOR INHIBITORS OF AUTOINHIBITED PROTEINS |
摘要 |
<p>Methods for obtaining highly target-specific inhibitory compounds are disclosed. These inhibitory compounds provide for the preservation of a native, non-activated form of an autoinhibited molecule, such as a protein or enzyme. The inhibitory compounds are further described as essentially free of inhibitory activity for non-native forms of an autoinhibited molecule of interest. By way of example, such autoinhibited molecules of interest include proteins and enzymes, such as the p-21-activated kinases (Paks) and the Rho-activated proteins. The inhibitory compounds act by binding to a distinct, autoinhibitory domain of an autoinhibited molecule (protein), and thereby stabilize an autoinhibited conformation of the molecule (protein). Preparations, including pharmaceutical preparations, compromising a composition enriched for the inhibitory compounds are also disclosed.</p> |
申请公布号 |
WO2006029337(A2) |
申请公布日期 |
2006.03.16 |
申请号 |
WO2005US32195 |
申请日期 |
2005.09.09 |
申请人 |
FOX CHASE CANCER CENTER;CHERNOFF, JONATHAN;PETERSON, JEFFREY, R. |
发明人 |
CHERNOFF, JONATHAN;PETERSON, JEFFREY, R. |
分类号 |
C40B40/10 |
主分类号 |
C40B40/10 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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