发明名称 |
RATIONALLY DESIGNED ANTIBODIES |
摘要 |
Antibodies or fragments thereof having CDR regions replaced or fused with biologically active peptides are described. Flanking sequences may optionally be attached at one or both the carboxy-terminal and amino-terminal ends of the peptide in covalent association with adjacent framework regions. Compositions containing such antibodies or fragments thereof are useful in therapeutic and diagnostic modalities. |
申请公布号 |
EP1370589(B1) |
申请公布日期 |
2006.03.15 |
申请号 |
EP20010985007 |
申请日期 |
2001.12.05 |
申请人 |
ALEXION PHARMACEUTICALS, INC. |
发明人 |
BOWDISH, KATHERINE, S.;BARBAS-FREDERICKSON, SHANA;RENSHAW, MARK |
分类号 |
C07K19/00;A61K39/00;A61K39/395;C07K14/475;C07K14/505;C07K14/52;C07K16/00;C07K16/12;C07K16/18;C07K16/46;C12N1/21;C12N15/13;C12N15/62;C12N15/70;G01N33/50;G01N33/573 |
主分类号 |
C07K19/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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