| 发明名称 |
GFR-ALPHA3 AND ITS USES |
| 摘要 |
<p>The present invention relates to nucleotide sequences, including expressed sequence tags (ESTs), oligonucleotide probes, polypeptides, vectors and host cells expressing, and immunoadhesions and antibodies to mammalian GFRalpha3, a novel alpha-subunit receptor of the GDNF (i.e. GFR) receptor family. It further relates to an assay for measuring activation of an alpha-subunit receptor by detecting tyrosine kinase receptor activation (i.e., autophosphorylation) or other activities related to ligand-induced alpha-subunit receptor homo-dimerization or homo-oligomerization.</p> |
| 申请公布号 |
EP1064376(B1) |
申请公布日期 |
2006.03.15 |
| 申请号 |
EP19990913993 |
申请日期 |
1999.03.19 |
| 申请人 |
GENENTECH, INC. |
发明人 |
DE SAUVAGE, FREDERIC, J.;KLEIN, ROBERT, D.;PHILLIPS, HEIDI, S.;ROSENTHAL, ARNON |
| 分类号 |
C12N15/12;G01N33/68;A61K39/395;A61K45/00;A61P1/02;A61P1/10;A61P11/06;A61P17/02;A61P25/02;A61P25/06;A61P27/02;C07K14/71;C07K16/28;C07K19/00;C12N1/19;C12N1/21;C12N5/10;C12N15/09;C12N15/70;C12N15/81;C12N15/85;C12Q1/42;G01N33/573 |
主分类号 |
C12N15/12 |
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