Synthesis of 2'-deoxy-L-nucleosides

摘要

The present invention provides a process for the preparation of a 2'-deoxy-L-nucleoside comprising the steps of:
a) preparing from a suitably protected and activated L-nucleoside a 2'-S-substituted-L-nucleoside of the following formula:
wherein B is a heterocyclic or heteroaromatic base, R 8 and R 9 are independently hydrogen or a suitable protecting group, R 6 is an alkyl or aryl, and m is 0, 1 or 2; and
b) reducing the 2'-S-substituted-L-nucleoside to a 2'-deoxy-L-nucleoside.