ETHANESULFONYL-PIPERIDINE DERIVATIVES

摘要

The invention relates to compounds of general formula (I) wherein R signify hydrogen or hydroxy; R2 signify hydrogen or methyl; and X signify -O- or -CH 2- ; and their pharmaceutically acceptable acid addition salts. It has been sho wn that these compounds have a good affinity to the NMDA receptor and they are therefore useful in the treatment of diseases, wherein the therapeutic indications include acute forms of neurodegeneration caused, e.g., by stroke or brain trauma; chronic forms of neurodegeneration such as Alzheimer's disease, Parkinsons's disease, Huntington's disease or ALS (amyotrophic lateral sclerosis); neurodegeneration associated with bacterial or viral infections, and, diseases such as schizophrenia, anxiety, depression and chronic/acute pain.