| 摘要 |
This invention relates to a novel crystalline diphosphate salt of (2R,3S,4R,5R,8R,10R,11R,12S ,13S,14R) -13- [[2,6-dideoxy-3-C-methyl- 3-O- methyl- 4-C- [(propylamino)methyl] -.alpha.-L-ribo- hexopryanosyl] oxy] -2-ethyl-3,4,10- trihydroxy- 3,5,8,10,12,14- hexamethyl- 11- [[3,4,6- trideoxy-3- (dimethylamino) -b-D-xylo-hexopyranosyl] oxy]-1-oxa-6-azacyclopentadecan-15-one that is useful as an antibacterial an d antiprotozoal agent in mammals. This invention also relates to pharmaceutica l compositions containing the free base of the diphosphate salt and the method s of treating bacterial and protozoal infections in mammals by administering t he free base of the diphosphate to mammals requiring such treatment. The free base of the diphosphate salt of the present invention possesses potent activity against various bacterial and protozoal infections when given by parenteral application to mammals.
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