| 摘要 |
FIELD: veterinary virology and biotechnology. ^ SUBSTANCE: claimed vaccine contains antigen material from infective cattle rinotracheitis virus strain, reproduced in specific passage cell cultures having biological activity of at least 6.0 lg TCD50/cm3 and inactivated with aminoethyl ethyleneimine, and oily adjuvant in mass ratio of 30.0:70.0, respectively. Aforementioned virus strain is reproduced in specific passage cell cultures and has cytopathic action and during incubation for 48-96 h in accumulated in titer of 6.5-8.0 lg TCD50/cm3. Aminoethyl ethyleneimine is used in concentration of 0.1-0.2 % followed by neutralization thereof with sodium thiosulfate. ^ EFFECT: vaccine with high antigenic and immunogenic activity and safety; enhanced assortment of specific agents for infective cattle rinotracheitis prophylaxis. ^ 15 cl, 6 tbl, 7 ex |
