Methods for determining the response of cells to vegf and uses thereof

摘要

The present invention provides methods of monitoring the progression of a disease condition associated with angiogenesis or vassculogenesis in a human subject in which a quantitative determination of the transcript level of at least one gene shown in Table 1 (by which is meant one or more of any of Tables 1a to 1f) in a sample comprising cells obtained from the site of said disease is made, and compared with the transcript level of at least one gene obtained from a control sample of cells. The transcripts of Table 1 are found to response to VEGF in a statistically significant manner under a variety of different conditions, including following serum withdrawal. The invention also provides gene chip arrays consisting of all or some of the transcripts together with appropriate controls which can be used in the methods described.