PROCESS FOR THE SYNTHESIS OF HIGH PURITY D-(17ALPHA)-13-ETHYL-17 -HYDROXY-18,19-DINORPRE:GN-4-ENE-20-YNE-3-ONE-OXIME.

摘要

The invention relates to a process for the synthesis of high purity d-(17alpha)-13-ethyl-17 -hydroxy-18,19-dinorpregn-4-ene-20-yne-3-one-oxime (further on norelgestromine) via acetylation of d-norgestrel at position 17, oximation of the oxo group at position 3 of the obtained 17-acetoxy derivative, and finally hydrolyzing the acetoxy group at position 17 of the obtained 3-oxime derivative. The process according to our invention is as foll.