PROCESS FOR PRODUCING DENDRITIC CELL HAVING ACQUIRED CTL INDUCING CAPABILITY

摘要

Elucidation of the mechanism of antigen cross-presentation of dendritic cells has been tackled, making it apparent that a foreign antigen taken in dendritic cells after having undergone polyubiquitination is decomposed by proteasome. Promotion of polyubiquitination has been attempted by multiple methods on the basis of novel finding that polyubiquitination takes part in the cross presentation, resulting in ascertaining of the promotion of antigen presentation. The above methods enable production of dendritic cells being active in CTL activation induction.