| 摘要 |
<p>The present invention relates to methods of treating an infectious, proliferative, or lymphocyte-mediated disease that involve providing a T cell receptor ß chain (TCR ß) having higher sensitivity recognition of antigen than a wild type TCR ß chain and introducing the TCR ß chain directly or indirectly to a subject having the disease under conditions effective to treat the disease. Also provided is another method of treating such diseases that involves providing an isolated mouse TCR ß chain having higher sensitivity recognition of antigen than a wild type TCR ß chain, linking the mouse TCR ß chain with a human TCR a a chain, and introducing the linked mouse TCR ß and human TCR a a chains to a subject having a disease, thereby treating the disease. The present invention also relates to a transgenic mouse having a TCR ß chain having higher sensitivity recognition of antigen than a wild type mouse.</p> |
