发明名称 |
PROCESS OF PREPARING A CRYSTALLINE AZITHROMYCIN MONOHYDRATE |
摘要 |
<p>The present invention provides a process of preparing a crystalline azithromycin monohydrate. The process involves dissolving azithromycin in a solution containing ethanol, adding the dissolved azithromycin into water to precipitate the crystals, isolating and drying the precipitate to a water content of about 5% (w/w) to about 7% (w/w). The resulting azithromycin monohydrate is stable, exhibiting less than 2% degradation, and non-hydroscopic.</p> |
申请公布号 |
WO2006025051(A2) |
申请公布日期 |
2006.03.09 |
申请号 |
WO2005IL00918 |
申请日期 |
2005.08.25 |
申请人 |
TARO PHARMACEUTICAL INDUSTRIES LTD.;GUTMAN, DANIELLA;SHACHEL, LEA |
发明人 |
GUTMAN, DANIELLA;SHACHEL, LEA |
分类号 |
C07H17/08;A61K31/7052 |
主分类号 |
C07H17/08 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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