METHODS AND MATERIALS RELATING TO ENHANCED PRODUCTION OF DOPAMINE NEURONS

摘要

Induction of neuronal fate in neural stem cells or neural progenitor or precursor cells, or other stem cells, and enhancement of induction of a specific neuronal phenotype, and particularly to induction and enhancement of induction of a midbrain dopaminergic neuronal phenotype. Expressing a nuclear receptor of the Nurr1 subfamily above basal levels within the cell, and regulating GSK-3ß inhibition within the cell other than by means of a ligand for a Frizzled receptor.