发明名称 Compositions and methods for enhancing analgesic potency of tramadol and attenuating its adverse side effects
摘要 The invention generally relates to compositions and methods with tramadol and an opioid antagonist to enhance analgesic potency and/or attenuate one or more adverse effects of tramadol, including adverse side effect(s) in humans such as nausea, vomiting, dizziness, headache, sedation (somnolence) or pruritis. This invention relates to compositions and methods for selectively enhancing the analgesic potency of tramadol and simultaneously attenuating anti-analgesia, hyperalgesia, hyperexcitability, physical dependence and/or tolerance effects associated with the administration of tramadol. The methods of the present invention comprise administering to a subject an analgesic or subanalgesic amount of tramadol and an amount of excitatory opioid receptor antagonist such as naltrexone or nalmefene effective to enhance the analgesic potency of tramadol and attenuate the anti-analgesia, hyperalgesia, hyperexcitability, physical dependence and/or tolerance effects of tramadol.
申请公布号 US2006052389(A1) 申请公布日期 2006.03.09
申请号 US20040894349 申请日期 2004.07.19
申请人 发明人 CRAIN STANLEY M.;SHEN KE-FEI;SHERMAN BARRY;REMIEN MARY;BARBIER REMI;FRIEDMANN NADAV
分类号 A61K31/496;A61K31/485 主分类号 A61K31/496
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